Kurata Keiji, Nishimura Sho, Ichikawa Hiroya, Sakai Rina, Mizutani Yu, Takenaka Kei, Kakiuchi Seiji, Miyata Yoshiharu, Kitao Akihito, Yakushijin Kimikazu, Kawamoto Shinichiro, Yamamoto Katsuya, Ito Mitsuhiro, Matsuoka Hiroshi, Tokimatsu Issei, Kamei Katsuhiko, Minami Hironobu
Department of Medical Oncology and Hematology, Kobe University Hospital, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Division of Infectious Diseases, Kobe University Hospital, Kobe, Japan.
Int J Hematol. 2018 Dec;108(6):658-664. doi: 10.1007/s12185-018-2496-1. Epub 2018 Jul 9.
Scopulariopsis alboflavescens is a soil saprophyte that is widely distributed in nature. Recently, there have been increasing number of reports of invasive infections with Scopulariopsis species in immunocompromised patients. In this report, we described an adult woman with acute myeloid leukemia and who developed S. alboflavescens pneumonia. Liposomal amphotericin B and voriconazole combination therapy was unsuccessful and the patient died because of pneumonia. Scopulariopsis is highly resistant to available antifungal agents and almost invariably fatal. This case report should alert clinicians to the importance of listing Scopulariopsis as a pathogenic fungus in immunocompromised patients.
淡黄帚霉是一种广泛分布于自然界的土壤腐生菌。最近，免疫功能低下患者中由帚霉属菌种引起的侵袭性感染报告越来越多。在本报告中，我们描述了一名成年女性急性髓系白血病患者，她患上了淡黄帚霉肺炎。脂质体两性霉素B和伏立康唑联合治疗未成功，患者因肺炎死亡。淡黄帚霉对现有的抗真菌药物高度耐药，几乎总是致命的。本病例报告应提醒临床医生注意将淡黄帚霉列为免疫功能低下患者致病真菌的重要性。
