Nataf V, Grapin-Botton A, Champeval D, Amemiya A, Yanagisawa M, Le Douarin N M
Institut d'Embryologie Cellulaire et Moléculaire du Centre National de la Recherche Scientifique et du Collège de France, 49 bis Avenue de la Belle Gabrielle, 94736, Nogent-sur-Marne Cedex, France.
Mech Dev. 1998 Jul;75(1-2):145-9. doi: 10.1016/s0925-4773(98)00079-3.
We investigated the expression pattern of the endothelin-A receptor and endothelin 1 genes, the mutations of which affect the development of the mesectodermal derivatives of the neural crest. We show here that endothelin 1 is expressed by the environment of the cephalic neural crest cells invading branchial arches. Later on, while the neural crest-derived tissues of the head continue to express endothelin-A receptor, endothelin 1 is no longer expressed in their environment.
