Stem Cell Medicine, O'Brien Institute, Melbourne, Australia.
Stem Cell Rev Rep. 2010 Sep;6(3):351-66. doi: 10.1007/s12015-010-9167-9.
Stem cells have great potential for understanding early development, treating human disease, tissue trauma and early phase drug discovery. The factors that control the regulation of stem cell survival, proliferation, migration and differentiation are still emerging. Some evidence now exists demonstrating the potent effects of various G-protein coupled receptor (GPCR) ligands on the biology of stem cells. This review aims to give an overview of the current knowledge of the regulation of embryonic and somatic stem cell maintenance and differentiation by GPCR ligands.
干细胞在理解早期发育、治疗人类疾病、组织创伤和药物早期发现方面具有巨大的潜力。控制干细胞存活、增殖、迁移和分化的调节因素仍在不断涌现。现在有一些证据表明，各种 G 蛋白偶联受体 (GPCR) 配体对干细胞的生物学特性具有强大的影响。本文综述了 GPCR 配体对胚胎和体干细胞维持和分化的调控的最新知识。
