Halbeck E, Dumps C, Bolkenius D
Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.
Anaesthesist. 2018 Aug;67(8):617-634. doi: 10.1007/s00101-018-0469-7.
Ketamine and midazolam form the endpoint of a series of articles about intravenous induction of anesthesia . Both substances can be used as single induction hypnotic drugs; however, in practice, this is unusual. Both substances, with the exception of a few very specific indications and clinical situations, are more frequently used in combination or with one of the more common alternatives propofol, barbiturates and etomidate. The reasons are the activity and side effects of both substances and their positive characteristics are used more as a supplement. In the concluding comparison the five discussed induction hypnotics are judged against each other. The use in certain clinical constellations and in special patient populations is evaluated individually for each substance. It is highlighted which drug appears most appropriate in which situation. As methohexital is nowadays only administered in very few clinical situations, this substance is not included in the comparative assessment.
氯胺酮和咪达唑仑构成了一系列关于静脉麻醉诱导文章的终点。这两种药物都可以用作单一诱导催眠药物；然而，在实践中，这种情况并不常见。除了一些非常特殊的适应症和临床情况外，这两种药物更常用于联合使用，或与更常用的替代药物丙泊酚、巴比妥类药物和依托咪酯之一联合使用。原因在于这两种药物的活性和副作用，它们的积极特性更多地用作补充。在最后的比较中，对讨论的五种诱导催眠药物进行了相互评判。针对每种药物，分别评估了其在某些临床情况和特殊患者群体中的使用情况。文中强调了哪种药物在何种情况下似乎最合适。由于美索比妥目前仅在极少数临床情况下使用，因此该药物未纳入比较评估。
