Ylä-Herttuala S
A.I. Virtanen Institute of Molecular Sciences, Kuopio, Finland.
Curr Opin Lipidol. 1998 Aug;9(4):337-44. doi: 10.1097/00041433-199808000-00009.
Basic research has provided strong evidence that oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Several mechanisms have been identified which can lead to LDL oxidation in vivo. Clinical and epidemiological studies have provided circumstantial evidence that oxidized LDL, as measured by serum autoantibody levels, may be associated with the progression of atherosclerotic vascular disease. This review discusses recent findings regarding the presence of oxidized LDL (ox-LDL) in vivo and the significance of ox-LDL autoantibody measurements as a tool to predict cardiovascular diseases in various patient populations.
基础研究已提供有力证据表明，低密度脂蛋白（LDL）的氧化在动脉粥样硬化发病机制中起重要作用。已确定了几种可导致体内LDL氧化的机制。临床和流行病学研究提供了间接证据，即通过血清自身抗体水平测定的氧化LDL可能与动脉粥样硬化性血管疾病的进展有关。本综述讨论了有关体内氧化LDL（ox-LDL）存在的最新发现，以及ox-LDL自身抗体测量作为预测不同患者群体心血管疾病工具的意义。
