肝脏疾病中的乙醇氧化酶活性
Ethanol oxidizing enzyme activites in liver disease.
作者信息
Dow J, Krasner N, Goldberg A
出版信息
Br J Clin Pharmacol. 1976 Jun;3(3):461-7. doi: 10.1111/j.1365-2125.1976.tb00622.x.
1 The activites of hepatic alcohol dehydrogenase, catalase and the reduced nicotinamide adenine dinucleotide phosphate (NADPH) dependent ethanol oxidizing system were determined in liver biopsies from nine patients with liver disease and seven control subjects with non evidence of liver disease. 2 Alcohol dehydrogenase and catalase activites were significantly lower in the patients with liver disease. 3 The activity of the NADPH dependent ethanol oxidizing system was significantly greater in the patients with liver disease, when its activity was expressed in terms of mg protein or g wet weight liver. 4 It is suggested that the greater activity of the NADPH dependent system may compensate for the low alcohol dehydrogenase activites found in patients with liver disease and maintain normal rates of ethanol metabolism.
- 测定了9例肝病患者和7例无肝病证据的对照者肝活检组织中肝乙醇脱氢酶、过氧化氢酶以及还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）依赖的乙醇氧化系统的活性。2. 肝病患者的乙醇脱氢酶和过氧化氢酶活性显著降低。3. 当以毫克蛋白或克肝湿重表示时，肝病患者中NADPH依赖的乙醇氧化系统活性显著更高。4. 提示NADPH依赖系统活性增强可能弥补了肝病患者中乙醇脱氢酶活性降低的情况，并维持正常的乙醇代谢速率。
Zotero 插件