Sekido Y, Fong K M, Minna J D
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas 75235-8593, USA.
Biochim Biophys Acta. 1998 Aug 19;1378(1):F21-59. doi: 10.1016/s0304-419x(98)00010-9.
We review the molecular pathogenesis of lung cancer including alterations in dominant oncogenes, recessive oncogenes/tumor suppressor genes, alterations in growth regulatory signaling pathways, abnormalities in other pathways, such as apoptosis, autocrine and paracrine growth stimulatory loops, angiogenesis, and host immune responses, other mechanisms of genetic changes, such as microsatellite and methylation alterations, and the potential for inherited predisposition to lung cancer. These changes are related to multistage carcinogenesis involving preneoplastic lesions, and lung development and differentiation. The translational applications of these findings for developing new ways of early detection, prevention, treatment, and prognosis of lung cancer are discussed.
我们综述了肺癌的分子发病机制，包括显性癌基因、隐性癌基因/肿瘤抑制基因的改变，生长调节信号通路的改变，其他通路的异常，如细胞凋亡、自分泌和旁分泌生长刺激环、血管生成和宿主免疫反应，遗传变化的其他机制，如微卫星和甲基化改变，以及肺癌遗传易感性的可能性。这些变化与涉及癌前病变、肺发育和分化的多阶段致癌作用有关。还讨论了这些发现对于开发肺癌早期检测、预防、治疗和预后新方法的转化应用。
