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[外阴克罗恩病:3例]

[Vulvar Crohn disease: 3 cases].

作者信息

Fenniche S, Mokni M, Haouet S, Ben Osman A

机构信息

Service de Dermatologie, Hôpital La Rabta, Tunis, Tunisie.

出版信息

Ann Dermatol Venereol. 1997;124(9):629-32.

PMID:9739928
Abstract

BACKGROUND

Vulvar involvement in Crohn's disease is uncommon. The elementary lesion is usually an ulceration: 44 cases have been reported in the literature. In 20 p. 100 of the cases, vulvar involvement is the only manifestation of the disease. We report 3 new cases of vulvar lesions in Crohn's disease.

CASE REPORTS

The first case had vulvar lesions which complicated ileocolic Crohn's disease, in the other two cases there were no digestive manifestations. One patient developed voluminous edema of the right labium. The diagnosis of Crohn's disease of the vulva was suggested by the characteristic lesions, presence of epithelioid and giant cell granuloma at histology examination of the vulva specimen and finally on rapidly favorable course after treatment with sulfasalazine. The ulcers regressed with medical treatment but remission was temporary with recurrence at treatment withdrawal.

DISCUSSION

These cases underline the difficulties encountered in establishing the diagnosis of Crohn's disease in patients who develop vulvar ulcerations alone with no signs of digestive disease and emphasize the difficult problem of long-term control.

摘要

背景

外阴部克罗恩病并不常见。基本病变通常为溃疡:文献中已报道44例。在100%的病例中,有20%外阴受累是该疾病的唯一表现。我们报告3例新的克罗恩病外阴病变病例。

病例报告

第一例患者的外阴病变使回结肠型克罗恩病复杂化,另外两例无消化系统表现。一名患者右侧阴唇出现大量水肿。外阴部标本组织学检查发现特征性病变、上皮样细胞和巨细胞肉芽肿,最终经柳氮磺胺吡啶治疗后病情迅速好转,提示为外阴部克罗恩病。溃疡经药物治疗后消退,但缓解是暂时的,停药后复发。

讨论

这些病例突显了在仅出现外阴溃疡而无消化系统疾病迹象的患者中诊断克罗恩病所遇到的困难,并强调了长期控制这一难题。

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