光敏剂和紫外线照射对前列腺素生物合成及代谢的影响。

The effects of photosensitizers and ultraviolet irradiation on the biosynthesis and metabolism of prostaglandins.

作者信息

Lord J T, Ziboh V A, Poitier J, Legget G, Penneys N S

出版信息

Br J Dermatol. 1976 Oct;95(4):397-405. doi: 10.1111/j.1365-2133.1976.tb00841.x.

DOI:10.1111/j.1365-2133.1976.tb00841.x

Abstract

Prostaglandin biosynthesis from arachidonic acid by skin microsomal fraction preparation was enhanced by UV-irradiation at wavelengths of 254 and 360 nm. In the presence of 8-methoxy psoralen (8 MOP) and coal tar, prostaglandin biosynthesis was further enhanced approximately 2-fold by UV-irradiation at 254 nm. Stimulation was less by UV-irradiation at 360 nm. 8-MOP enhanced the conversion of PGE2 into PGF2-9-ketoreductase prepared from skin high speed supernatant fractions. UV-irradiation at 254 nm and 360 nm with or without the photosensitizers had no effect on the activity of the PGE2-9-ketoreductase. These data therefore indicate that the action of UV-irradiation, 8-methoxy psoralen and coal tar on the skin may in part be due to their regulation of the biosynthesis and metabolism of prostaglandins in this tissue.

摘要

皮肤微粒体部分制剂从花生四烯酸合成前列腺素的过程，在波长为254和360纳米的紫外线照射下得到增强。在存在8-甲氧基补骨脂素（8-MOP）和煤焦油的情况下，254纳米的紫外线照射使前列腺素的生物合成进一步增强了约2倍。360纳米的紫外线照射刺激作用较小。8-MOP增强了从皮肤高速上清液部分制备的PGE2向PGF2 - 9-酮还原酶的转化。254纳米和360纳米的紫外线照射，无论有无光敏剂，对PGE2 - 9-酮还原酶的活性均无影响。因此，这些数据表明紫外线照射、8-甲氧基补骨脂素和煤焦油对皮肤的作用，可能部分归因于它们对该组织中前列腺素生物合成和代谢的调节。