Chung P H, Palermo G, Schlegel P N, Veeck L L, Eid J F, Rosenwaks Z
The Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, The New York Hospital-Cornell Medical Center, New York 10021, USA.
Hum Reprod. 1998 Jul;13(7):1854-8. doi: 10.1093/humrep/13.7.1854.
Electroejaculation has been successfully used for sperm procurement in anejaculatory men desiring fertility. However, electroejaculates typically have normal sperm numbers but poor motility, morphology, and functional deficiencies. Here we report the pregnancy outcome of a series of couples undergoing combined electroejaculation and in-vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). In all, 13 couples underwent a total of 18 cycles. The aetiologies of anejaculation included history of retroperitoneal lymph node dissection for testicular cancers, spinal cord injury and psychogenic causes. ICSI was performed on 192 oocytes, resulting in a fertilization rate of 75.5%. A total of 15 embryo transfers were performed using a total of 51 embryos. Clinical pregnancy rate, as defined by positive fetal heart rate(s) using vaginal sonography, was 55.6% per retrieval; implantation rate was 33.3% per embryo. These rates appear to be similar to those obtained in standard IVF for non-male factor infertility, or ICSI for male factor infertility. The use of ICSI for electroejaculates undoubtedly provides these couples with the highest chance of pregnancy.
对于渴望生育的射精障碍男性，电射精已成功用于获取精子。然而，电射精获得的精液通常精子数量正常，但活力差、形态异常且存在功能缺陷。在此，我们报告一系列接受电射精与体外受精（IVF）联合卵胞浆内单精子注射（ICSI）治疗的夫妇的妊娠结局。共有13对夫妇进行了总共18个周期的治疗。射精障碍的病因包括因睾丸癌行腹膜后淋巴结清扫术史、脊髓损伤和精神因素。对192个卵母细胞进行了ICSI，受精率为75.5%。共使用51个胚胎进行了15次胚胎移植。根据经阴道超声检查出现胎心搏动定义的临床妊娠率为每次取卵55.6%；胚胎着床率为每个胚胎33.3%。这些比率似乎与非男性因素不孕的标准IVF或男性因素不孕的ICSI所获得的比率相似。对电射精精液使用ICSI无疑为这些夫妇提供了最高的妊娠机会。
