Söderström-Anttila V, Sajaniemi N, Tiitinen A, Hovatta O
Infertility Clinic, The Family Federation of Finland, Helsinki.
Hum Reprod. 1998 Jul;13(7):2009-15. doi: 10.1093/humrep/13.7.2009.
The health, growth and development of a cohort of children (n = 59) aged 6 months to 4 years and born after oocyte donation (OD) was compared with that from a group of children born after in-vitro fertilization (IVF) (n = 126). The study was performed by questionnaire, and the response rate was 100% in the OD group and 95% in the IVF group. All OD children were healthy. Three IVF children had a neurological disorder. Surgical intervention had been carried out in 8% of the OD and 13% of the IVF children. Height and weight development were normal, and eating and sleeping disorders were uncommon in both groups of children. The IVF mothers more often expressed concern about the child's behaviour than did the OD mothers. Thirty-eight percent of the OD parents and 60% of the IVF parents intended to tell the child about the nature of its conception (P < 0.01). Although oocyte recipients appear to have more complications during their pregnancies than conventional IVF patients, the general health status of OD children aged <5 years is at least as good as that of IVF children. Growth and development in both groups of children is similar to that of the general population.
将一组6个月至4岁、通过卵母细胞捐赠（OD）出生的儿童（n = 59）的健康、生长和发育情况与一组通过体外受精（IVF）出生的儿童（n = 126）进行比较。该研究通过问卷调查进行，OD组的回复率为100%，IVF组为95%。所有OD儿童均健康。3名IVF儿童患有神经疾病。8%的OD儿童和13%的IVF儿童接受过手术干预。两组儿童的身高和体重发育正常，饮食和睡眠障碍并不常见。IVF母亲比OD母亲更常表达对孩子行为的担忧。38%的OD父母和60%的IVF父母打算告知孩子其受孕的性质（P < 0.01）。尽管卵母细胞接受者在孕期似乎比传统IVF患者有更多并发症，但5岁以下OD儿童的总体健康状况至少与IVF儿童一样好。两组儿童的生长和发育与一般人群相似。
