Bechdolf A, Halve S, Schultze-Lutter F, Klosterkötter J
Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität zu Köln.
Fortschr Neurol Psychiatr. 1998 Aug;66(8):378-86. doi: 10.1055/s-2007-995275.
For the first time, the present study explores self-experienced vulnerability, prodromal symptoms and coping strategies preceding schizophrenic and affective episodes. 33 schizophrenic and 29 depressive patients were assessed retrospectively for preepisodic alterations by means of the "Bonn Scale for the Assessment of Basic Symptoms- BSABS" after complete recovery from the acute episode. 97% of the schizophrenic and 93% of the depressive patients showed preepisodic alterations. In the schizophrenic group the first alteration occurred with a median of 10 weeks and in the depressive group with a median of 18 weeks before the onset of the acute episode. With regard to self-experienced vulnerability depressive cases were significantly less tolerant to stress, i.e work under time pressure or unusual, unexpected requirements. With regard to prodromal symptoms schizophrenics showed significantly more often interpersonal irritation and certain perception and thought disturbances, whereas depressive patients reported more often adynamia and certain disturbances of proprioception. 73% of the schizophrenic patients and 90% of the depressive patients reacted to early symptoms with coping strategies. The preepisodic alterations in schizophrenic patients could be described in terms of mild psychotic productivity, early symptoms of depressive patients could be described as a mild depressive syndrome. Prospective studies are necessary to show if assessment of mild psychotic productivity could be used for early diagnosis and early intervention in schizophrenia.
本研究首次探讨了精神分裂症发作和情感发作之前的自我体验到的易感性、前驱症状及应对策略。在33例精神分裂症患者和29例抑郁症患者从急性发作完全康复后,采用“波恩基本症状评估量表 - BSABS”对发作前的改变进行了回顾性评估。97%的精神分裂症患者和93%的抑郁症患者显示有发作前改变。在精神分裂症组中,首次改变发生在急性发作前中位数为10周时,而在抑郁症组中,首次改变发生在急性发作前中位数为18周时。关于自我体验到的易感性,抑郁症患者对压力(即在时间压力下工作或面对不寻常、意外的要求)的耐受性明显较低。关于前驱症状,精神分裂症患者更常出现人际间的刺激以及某些感知和思维障碍,而抑郁症患者更常报告乏力和某些本体感觉障碍。73%的精神分裂症患者和90%的抑郁症患者会采用应对策略来应对早期症状。精神分裂症患者发作前的改变可描述为轻度精神病性产出,抑郁症患者的早期症状可描述为轻度抑郁综合征。需要进行前瞻性研究以确定对轻度精神病性产出的评估是否可用于精神分裂症的早期诊断和早期干预。