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利用计算机数据库预测并避免癌症患者使用精神药物时的药物相互作用。

Using computer databases to predict and avoid drug-drug interactions in the cancer patient requiring psychotropics.

作者信息

Strain J J, Caliendo G, Himelein C

机构信息

Mount Sinai Medical Center, Department of Psychiatry, New York, NY 10029, USA.

出版信息

Psychooncology. 1998 Jul-Aug;7(4):321-32. doi: 10.1002/(SICI)1099-1611(199807/08)7:4<321::AID-PON363>3.0.CO;2-S.

Abstract

Psychotropic drug interactions with medical prescriptions is an essential knowledge base for the practicing oncologist as well as the psychiatrist. This paper describes a method to identify, understand, and develop a conceptual framework to codify psychotropic-medical drug interactions; a systemic approach for updating this key database, and a software system to assist in the management of this ever unfolding sphere of knowledge; and, a set of instruments to provide ongoing developments in this important area. Since many of the trials either for oncological medications or psychotropic drugs did not include studies comparing these two domains, their interactions often only become known with their utilization and subsequent reporting.

摘要

精神药物与医学处方之间的相互作用是执业肿瘤学家和精神科医生必备的知识库。本文描述了一种识别、理解并建立一个概念框架以编纂精神药物与医学药物相互作用的方法;一种更新这个关键数据库的系统方法,以及一个辅助管理这个不断发展的知识领域的软件系统;还有一套用于推动这一重要领域持续发展的工具。由于许多肿瘤药物或精神药物的试验并未包括比较这两个领域的研究,它们之间的相互作用往往只有在使用及后续报告后才为人所知。

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