终末期结节病肺移植的中期结果。
Medium term results of lung transplantation for end stage pulmonary sarcoidosis.
作者信息
Walker S, Mikhail G, Banner N, Partridge J, Khaghani A, Burke M, Yacoub M
机构信息
Transplant Unit, Harefield Hospital, Middlesex, UK.
出版信息
Thorax. 1998 Apr;53(4):281-4. doi: 10.1136/thx.53.4.281.
BACKGROUND
Lung transplantation is an accepted therapeutic option for patients with end stage pulmonary sarcoidosis. However, the medium term outcome of transplantation in this patient group is unknown.
METHODS
This study was performed to evaluate our experience with lung transplantation for end stage pulmonary sarcoidosis. Between July 1988 and July 1997 12 patients (nine men) underwent lung transplantation for sarcoidosis at our institution. Ten underwent single lung transplantation and two double lung transplantation.
RESULTS
Survival at three and five years was 70% and 56%, respectively. Three patients developed obliterative bronchiolitis at six, 18, and 45 months. One died at the time of retransplantation. Sarcoid granulomas have recurred in the donor organ in three patients. In one the development of granulomas has been associated with clinical deterioration, necessitating retransplantation. Mean (SD) forced expiratory volumes in one second at three and five years were 1.37 (0.67) 1 and 1.34 (0.13) 1, respectively.
CONCLUSIONS
Lung transplantation is a viable option for patients with end stage pulmonary sarcoidosis. The medium term results are comparable with patients undergoing lung transplantation for other indications. Despite histological recurrence of sarcoidosis, the risk of clinically important recurrence is low.
背景
肺移植是终末期结节病患者可接受的治疗选择。然而，该患者群体移植的中期结果尚不清楚。
方法
本研究旨在评估我们对终末期结节病患者进行肺移植的经验。1988年7月至1997年7月期间，我们机构有12例患者（9名男性）因结节病接受了肺移植。10例行单肺移植，2例行双肺移植。
结果
3年和5年生存率分别为70%和56%。3例患者在6个月、18个月和45个月时发生闭塞性细支气管炎。1例在再次移植时死亡。3例患者供体器官中出现结节病肉芽肿复发。其中1例肉芽肿的出现与临床病情恶化相关，需要再次移植。3年和5年时一秒用力呼气量的均值（标准差）分别为1.37（0.67）升和1.34（0.13）升。
结论
肺移植是终末期结节病患者的可行选择。中期结果与因其他适应证接受肺移植的患者相当。尽管结节病有组织学复发，但具有临床意义的复发风险较低。
Zotero 插件