Donnez J, Bassil S
Department of Gynecology, Catholic University of Louvain, University Clinics St-Luc, Brussels, Belgium.
Hum Reprod Update. 1998 May-Jun;4(3):248-59. doi: 10.1093/humupd/4.3.248.
For patients who are planning to have chemotherapy, radiotherapy or to undergo bilateral oophorectomy, loss of ovarian function will result in premature ovarian menopause and loss of fertility. For these women, although there is no successful method for the cryopreservation of human oocytes, ovarian tissue cryobanking is proposed with a view to its autotransplantation at a later date or the isolation and in-vitro maturation of oocytes. Embryo preservation is indeed not an option for single women and even for married women because delaying treatment for at least 2 months of in-vitro fertilization cycles is inappropriate and life-threatening. Following the success of animal experiments, there have been reports of ovarian cryopreservation for women having to receive chemotherapy and/or radiotherapy. We present four case reports of ovarian tissue cryobanking and review the consequences of chemotherapy and radiotherapy on gonadal function, as well as the indications for freezing ovarian tissue.
对于计划接受化疗、放疗或双侧卵巢切除术的患者，卵巢功能丧失将导致卵巢过早绝经和生育能力丧失。对于这些女性，尽管目前尚无成功的人类卵母细胞冷冻保存方法，但有人提出进行卵巢组织冷冻保存，以期日后进行自体移植或分离并体外成熟卵母细胞。胚胎保存对于单身女性甚至已婚女性来说都不是一个选择，因为将治疗推迟至少2个月进行体外受精周期既不合适又危及生命。在动物实验取得成功之后，已有关于为必须接受化疗和/或放疗的女性进行卵巢冷冻保存的报道。我们呈现四例卵巢组织冷冻保存的病例报告，并综述化疗和放疗对性腺功能的影响以及冷冻卵巢组织的指征。
