Fenton E, Britton H G, Nixon D A
Biol Neonate. 1976;29(5-6):299-305. doi: 10.1159/000240879.
The role of the guinea pig placenta in fetal citrate metabolism has been studied by perfusing the placenta in situ. The initial citrate concentrations in the perfusate plasma were lower than in the maternal plasma but rose progressively until, in some cases, they exceeded those in the mother. The rise was uninfluenced by intravenous administration of citrate to the mother. Citrate therefore does not enter the perfusate by simple diffusion from the maternal compartment. It may be synthesised within the placenta. From the rate of accumulation of citrate in the perfusate, the supply to the fetus was calculated to be small compared to the fetal metabolic rate. Citrate added to the perfusate became distributed in a space similar to the extracellular space and no change occurred in maternal citrate concentrations. Thus, the placenta does not appear to metabolise citrate or allow transport to the mother.
通过对豚鼠胎盘进行原位灌注，研究了其在胎儿柠檬酸代谢中的作用。灌注液血浆中的初始柠檬酸浓度低于母体血浆中的浓度，但逐渐升高，在某些情况下，甚至超过了母体血浆中的浓度。向母体静脉注射柠檬酸并不会影响这一升高过程。因此，柠檬酸并非通过从母体隔室简单扩散进入灌注液。它可能是在胎盘内合成的。根据灌注液中柠檬酸的积累速率计算，与胎儿代谢率相比，向胎儿的供应较少。添加到灌注液中的柠檬酸分布在类似于细胞外空间的区域，母体柠檬酸浓度没有变化。因此，胎盘似乎不会代谢柠檬酸，也不会将其转运至母体。
