Games D E, Rossiter M, Rogers M S, Weston A, Parfitt R T
Biomed Mass Spectrom. 1976 Oct;3(5):232-4. doi: 10.1002/bms.1200030508.
Gentamicin sulphate employed in therapeutics consists of a mixture of three major aminoglycoside components, the gentamicins C1, C1a and C2. In the electron impact mass spectra of these components weak parent ions may be observed but they are of no diagnostic value in the commercial mixture. Chemical ionization and field desorption spectra of individual gentamicin components and commercial mixtures are reported and discussed. Isobutane chemical ionization spectra exhibit some fragmentation, but under optimum field desorption conditions little glycosidic cleavage is observed and [M + H]+ ions dominate the spectra.
用于治疗的硫酸庆大霉素由三种主要氨基糖苷类成分（庆大霉素C1、C1a和C2）的混合物组成。在这些成分的电子轰击质谱中，可能会观察到微弱的母离子，但它们对商业混合物没有诊断价值。本文报道并讨论了各庆大霉素成分及商业混合物的化学电离和场解吸光谱。异丁烷化学电离光谱显示出一些碎片化，但在最佳场解吸条件下，几乎观察不到糖苷键断裂，[M + H]+离子主导光谱。
