Nagano K, Koga M, Yuki N
Department of Neurology, Chikamori Hospital, Kochi, Japan.
Rinsho Shinkeigaku. 1998 Apr;38(4):333-5.
A 36-year-old man with pharyngeal-cervical-brachial variant of Guillain-Barré syndrome (PCB) was described. Neurologic examination revealed total ophthalmoplegia, pharyngeal-cervical-brachial weakness and hyporeflexia in the upper limbs, sparing power and tendon reflexes in the lower limbs. Enzyme-linked immunosorbent assay showed that he had high titer of IgG antibody to GT1a (1:32,000), which did not cross-react with GQ1 b or GD1a. Thin-layer chromatography immunostaining confirmed that his serum IgG reacted with GT1a. These findings show that IgG anti-GT1a antibody without cross-reactivity with GQ1b plays a role in the development of PCB.
本文描述了一名患有吉兰-巴雷综合征（Guillain-Barré syndrome，GBS）咽颈臂变异型（PCB）的36岁男性。神经系统检查发现患者存在完全性眼肌麻痹、咽颈臂肌无力以及上肢反射减退，而下肢肌力和腱反射正常。酶联免疫吸附测定显示，他对GT1a的IgG抗体滴度很高（1:32,000），且该抗体与GQ1b或GD1a无交叉反应。薄层色谱免疫染色证实，他的血清IgG与GT1a发生反应。这些发现表明，不与GQ1b发生交叉反应的IgG抗GT1a抗体在PCB的发病过程中起作用。
