Stüben G, Stuschke M, Knühmann K, Pöttgen C, Sack H
Department of Radiotherapy, Universitätsklinikum Essen, Germany.
Acta Oncol. 1998;37(4):369-73. doi: 10.1080/028418698430593.
The effects of tissue damage associated with invasive pO2 measurements on radiation sensitivity were investigated using a xenografted squamous cell carcinoma model. For the tumour cure experiments, single dose irradiations were given following different regimens of polarographic pO2 measurements associated with different degrees of mechanical tissue damage. With a dose of 32 Gy, 57% of animals were cured. Following 3 tracks of needle measurements, 73% of tumours were locally controlled, and 75% were cured after 8 needle tracks. The polarographic measurements gave virtually identical oxygenation data for recurrent or cured tumours (both median pO2 1.0 mmHg), respectively. There was thus no evidence of decreased radiosensitivity associated with tissue damage after invasive pO2 measurements. The pre-therapeutic oxygenation status gave no evidence for a prediction of radiation response on an individual basis.
使用异种移植鳞状细胞癌模型研究了与侵入性氧分压（pO2）测量相关的组织损伤对放射敏感性的影响。对于肿瘤治愈实验，在与不同程度机械组织损伤相关的极谱法pO2测量的不同方案之后进行单次剂量照射。给予32 Gy的剂量时，57%的动物被治愈。在进行3次针吸测量后，73%的肿瘤得到局部控制，在进行8次针吸测量后，75%的肿瘤被治愈。极谱测量分别为复发性或治愈性肿瘤提供了几乎相同的氧合数据（两者的pO2中位数均为1.0 mmHg）。因此，没有证据表明侵入性pO2测量后与组织损伤相关的放射敏感性降低。治疗前的氧合状态没有提供个体放射反应预测的证据。
