Shafik A
Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Egypt.
J Invest Surg. 1998 May-Jun;11(3):199-205. doi: 10.3109/08941939809098034.
To study the effect of gallbladder (GB) distension on the sphincter of Oddi (SO), 9 mongrel dogs (mean weight 15.3+/-3.6 kg) were studied. Under anesthesia, the abdomen was opened and the GB and SO were exposed. A balloon-tipped catheter was introduced into the GB and a manometric catheter into the common bile duct so that its fluoroscopically controlled tip lay within the SO. The pressure response of the GB and SO to GB distension by the balloon without and with selective anesthetization of the GB and SO was recorded. The test was repeated in four vagotomized dogs. GB distension effected pressure rise within the GB and pressure drop within the SO. The GB pressure increased progressively as the distending volume increased, while the SO pressure drop was not affected. Selective anesthetization of the GB or the SO produced no SO pressure changes upon GB distension. The SO pressure response to GB distension after vagotomy was similar to that before vagotomy. The SO relaxation on GB contraction, being reproducible and abolished by selective anesthetization of either the SO or the GB, postulates a reflex relationship that we call the cholecysto-sphincter inhibitory reflex. This reflex seems to regulate the bile flow from the GB to the duodenum through the SO.
为研究胆囊扩张对Oddi括约肌（SO）的影响，对9只杂种犬（平均体重15.3±3.6千克）进行了研究。在麻醉状态下，打开腹腔，暴露胆囊和Oddi括约肌。将带气囊导管插入胆囊，将测压导管插入胆总管，使荧光镜控制下的导管尖端位于Oddi括约肌内。记录在胆囊无选择性麻醉和有选择性麻醉情况下，胆囊扩张时胆囊和Oddi括约肌的压力反应。在4只迷走神经切断的犬身上重复该试验。胆囊扩张导致胆囊内压力升高，Oddi括约肌内压力下降。随着扩张容积增加，胆囊压力逐渐升高，而Oddi括约肌压力下降不受影响。对胆囊或Oddi括约肌进行选择性麻醉后，胆囊扩张时Oddi括约肌压力无变化。迷走神经切断后Oddi括约肌对胆囊扩张的压力反应与切断前相似。胆囊收缩时Oddi括约肌松弛，这种现象可重复出现，并且通过对Oddi括约肌或胆囊进行选择性麻醉可消除，这表明存在一种反射关系，我们称之为胆囊 - 括约肌抑制反射。这种反射似乎通过Oddi括约肌调节胆汁从胆囊流向十二指肠。
