Shafik A
Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Egypt.
World J Surg. 1998 Oct;22(10):1061-4. doi: 10.1007/s002689900517.
The mechanical effect of balloon distension of the duodenum on the stomach was studied in 10 mongrel dogs with a mean weight of 14.8 +/- 3.2 kg. The response of the pyloric sphincter and antrum as well as of the corpus of the stomach to duodenal distension by a balloon filled with water in increments of 2 ml, up to 6 ml, was determined. The test was repeated after anesthetizing the pyloric sphincter and antrum and the duodenum, each at a separate time. In 5 of 10 dogs the effect of duodenal distension on the vagotomized stomach was studied. Duodenal distension with 2 ml of water produced an increase in the pyloric sphincter pressure (p < 0.05) and a decrease in the antral pressure (p < 0.05); it had no effect on corporeal pressure (p > 0.05). Distension with 4 ml and 6 ml produced the same effect as 2 ml (p > 0.05). The anesthetized pyloric sphincter and antrum did not respond to duodenal distension. Likewise, the pyloric sphincter and antrum showed no response to distension of the anesthetized duodenum or of the duodenum after vagotomy. Pyloric sphincter contraction and antral dilatation upon duodenal distension suggest a reflex relation we call the duodenopyloric reflex. This reflex appears to prevent duodenopyloric reflux. Moreover, the antrum dilates probably to accommodate more gastric contents.
在10只平均体重为14.8±3.2千克的杂种狗身上，研究了十二指肠球囊扩张对胃的机械效应。通过向球囊内以2毫升递增直至6毫升的量注入水来确定十二指肠扩张时幽门括约肌、胃窦以及胃体的反应。在分别麻醉幽门括约肌和胃窦以及十二指肠后重复该试验。在10只狗中的5只身上研究了十二指肠扩张对迷走神经切断术后胃的影响。注入2毫升水使十二指肠扩张会导致幽门括约肌压力升高（p<0.05）以及胃窦压力降低（p<0.05）；对胃体压力无影响（p>0.05）。注入4毫升和6毫升水时产生的效果与注入2毫升时相同（p>0.05）。麻醉后的幽门括约肌和胃窦对十二指肠扩张无反应。同样，幽门括约肌和胃窦对麻醉后的十二指肠或迷走神经切断术后的十二指肠扩张也无反应。十二指肠扩张时幽门括约肌收缩和胃窦扩张提示了一种我们称之为十二指肠 - 幽门反射的反射关系。这种反射似乎可防止十二指肠 - 幽门反流。此外，胃窦扩张可能是为了容纳更多的胃内容物。
