Cho C, Bunch D O, Faure J E, Goulding E H, Eddy E M, Primakoff P, Myles D G
Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA.
Science. 1998 Sep 18;281(5384):1857-9. doi: 10.1126/science.281.5384.1857.
Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm. Sperm from mice lacking fertilin beta were shown to be deficient in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus into the oviduct, and binding to the egg zona pellucida. Egg activation was unaffected. The results are consistent with a direct role of fertilin in sperm-egg plasma membrane interaction. Fertilin could also have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis.
受精素是ADAM家族的一员，存在于哺乳动物精子的质膜上。研究表明，缺乏受精素β的小鼠精子在精卵膜黏附、精卵融合、从子宫向输卵管迁移以及与卵透明带结合方面存在缺陷。卵激活不受影响。这些结果与受精素在精卵质膜相互作用中起直接作用一致。受精素也可能在精子与透明带结合或输卵管迁移中起直接作用；或者，对这些功能的影响可能是由于精子发生过程中缺乏受精素活性所致。
