Liu Meng-Meng, Feng Xin-Lei, Qi Chao, Zhang Shu-Er, Zhang Guo-Liang
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, Shandong, China.
Animal Products Quality and Safety Center of Shandong Province, Jinan, Shandong, China.
Front Cell Dev Biol. 2024 Mar 21;12:1357370. doi: 10.3389/fcell.2024.1357370. eCollection 2024.
As a crucial component of the male reproductive system, the epididymis plays multiple roles, including sperm storage and secretion of nutritive fluids for sperm development and maturation. The acquisition of fertilization capacity by sperm occurs during their transport through the epididymis. Compared with the testis, little has been realized about the importance of the epididymis. However, with the development of molecular biology and single-cell sequencing technology, the importance of the epididymis for male fertility should be reconsidered. Recent studies have revealed that different regions of the epididymis exhibit distinct functions and cell type compositions, which are likely determined by variations in gene expression patterns. In this research, we primarily focused on elucidating the cellular composition and region-specific gene expression patterns within different segments of the epididymis and provided detailed insights into epididymal function in male fertility.
作为男性生殖系统的关键组成部分，附睾发挥着多种作用，包括储存精子以及分泌营养液以促进精子的发育和成熟。精子在通过附睾运输的过程中获得受精能力。与睾丸相比，附睾的重要性尚未得到充分认识。然而，随着分子生物学和单细胞测序技术的发展，附睾对男性生育能力的重要性应重新审视。最近的研究表明，附睾的不同区域具有不同的功能和细胞类型组成，这可能由基因表达模式的差异所决定。在本研究中，我们主要致力于阐明附睾不同节段内的细胞组成和区域特异性基因表达模式，并深入了解附睾在男性生育中的功能。
