D型与L型色氨酸对犬脑内5-羟色胺和多巴胺代谢的比较。
A comparison of D and L-tryptophan on the cerebral metabolism of 5-hydroxytryptamine and dopamine in the dog.
作者信息
Budny J, Dow R C, Eccleston D, Hill A G, Ritchie I M
出版信息
Br J Pharmacol. 1976 Sep;58(1):3-7. doi: 10.1111/j.1476-5381.1976.tb07686.x.
Abstract
1 After D and L-tryptophan (50 mg/kg) were given intravenously in the dog, the concentration of the amino acid was increased in ventricular cerebrospinal fluid (CSF) during the subsequent 4 h or sampling, although the concentrations were significantly lower following the administration of the D-isomer. 2 There was no evidence that D-tryptophan increased the synthesis of 5-hydroxytryptamine (5-HT) in dog brain as judged by the failure to cause a change in 5-hydroxyindoleacetic acid (5-HIAA) concentrations in ventricular CSF different from that seen with controls. 3 There was no appreciable conversion of D-tryptophan to L-tryptophan in the dog. 4 D-tryptophan was cleared more rapidly from plasma than L-tryptophan. 5 No difference in plasma binding between D and L-tryptophan was detected.
摘要
- 给犬静脉注射D-色氨酸和L-色氨酸（50毫克/千克）后，在随后4小时的采样过程中，脑室脑脊液（CSF）中氨基酸浓度升高，不过给予D-异构体后浓度显著更低。2. 没有证据表明，从脑室CSF中5-羟吲哚乙酸（5-HIAA）浓度未出现不同于对照组的变化判断，D-色氨酸会增加犬脑中5-羟色胺（5-HT）的合成。3. 在犬体内，D-色氨酸没有明显转化为L-色氨酸。4. D-色氨酸从血浆中的清除速度比L-色氨酸更快。5. 未检测到D-色氨酸和L-色氨酸在血浆结合方面存在差异。
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本文引用的文献
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The influence of optical isomerism and acetylation upon the availability of tryptophan for maintenance in man.光学异构现象和乙酰化作用对人体维持所需色氨酸可利用性的影响。
J Nutr. 1949 Oct 10;39(2):203-18. doi: 10.1093/jn/39.2.203.
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A fluorometric procedure for the measurement of tryptamine in tissues.一种用于测量组织中色胺的荧光测定法。
J Pharmacol Exp Ther. 1959 Nov;127:175-7.
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The specific binding of L-tryptophan to serum albumin.L-色氨酸与血清白蛋白的特异性结合。
J Biol Chem. 1958 Dec;233(6):1436-47.
5
Physiology of the D-amino acids.D-氨基酸的生理学
Physiol Rev. 1953 Apr;33(2):145-89. doi: 10.1152/physrev.1953.33.2.145.
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Tryptophan requirement for growth and utilization of its optical isomers.色氨酸对生长及其旋光异构体利用的需求。
J Biol Chem. 1952 May;196(1):33-43.
7
The nature of in vitro hydroxylation of L-tryptophan by brain tissue.脑组织对L-色氨酸的体外羟基化作用的性质。
J Neurochem. 1966 Aug;13(8):643-54. doi: 10.1111/j.1471-4159.1966.tb09872.x.
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Some studies of the effects of chlorpromazine, reserpine and dihydroxyphenylalanine on the concentrations of homovanillic acid, 3,4-dihydroxyphenylacetic acid and 5-hydroxyindol-3-ylacetic acid in ventricular cerebrospinal fluid of the dog using the technique of serial sampling of the cerebrospinal fluid.一些关于氯丙嗪、利血平和二羟基苯丙氨酸对犬脑室脑脊液中高香草酸、3,4-二羟基苯乙酸和5-羟基吲哚-3-乙酸浓度影响的研究，采用了脑脊液连续采样技术。
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