Igari J, Oguri T, Tachibana Y, Misawa N, Nakamura A, Shitara M, Umezu S, Nakamura Y, Tazawa S, Shimoura M, Ugajin K, Mori T, Shimada J, Kaku M, Murase M, Hirakata Y, Matsuda J
Department of Clinical Pathology, Juntendo University School of Medicine.
Jpn J Antibiot. 1997 Jul;50(7):640-9.
The purpose of our investigation was to monitor current trends in the susceptibility patterns of clinical bacterial isolates to roxithromycin (RXM). We measured the MICs of macrolide antibiotics, such as RXM, erythromycin (EM), clarithromycin (CAM), rokitamycin (RKM) and midecamycin (MDM), and other classes of antibacterial compounds against various clinical isolates at seven institutions between October and December in 1994 and 1995. RXM had excellent antibacterial activities for S. pyogenes, S. agalactiae, M. (B.) catarrhalis and methicillin sensitive S. aureus. Against methicillin sensitive S. epidermidis, RXM activity was fairly good but about 20% of the strains had MIC > or = 128 micrograms/ml. The activity against S. pneumoniae was not so potent and similar to activities of EM, CAM, MDM, and clindamycin. The vast majority of methicillin resistant S. aureus and S. epidermidis were also resistant to macrolide antibiotics and other classes of compounds tested. In conclusion, RXM is an unique macrolide antibiotic by retaining potent activity against S. pyogenes, S. agalactiae, S. aureus except MRSA, M. (B.) catarrhalis and M. pneumoniae.
我们调查的目的是监测临床分离细菌对罗红霉素（RXM）敏感性模式的当前趋势。我们在1994年和1995年10月至12月期间，测量了罗红霉素、红霉素（EM）、克拉霉素（CAM）、罗他霉素（RKM）和麦迪霉素（MDM）等大环内酯类抗生素以及其他各类抗菌化合物对七个机构各种临床分离株的最低抑菌浓度（MIC）。罗红霉素对化脓性链球菌、无乳链球菌、卡他莫拉菌（B群）和甲氧西林敏感金黄色葡萄球菌具有优异的抗菌活性。对于甲氧西林敏感表皮葡萄球菌，罗红霉素活性相当好，但约20%的菌株MIC≥128微克/毫升。其对肺炎链球菌的活性不强，与红霉素、克拉霉素、麦迪霉素和克林霉素的活性相似。绝大多数耐甲氧西林金黄色葡萄球菌和表皮葡萄球菌也对大环内酯类抗生素和其他测试的化合物耐药。总之，罗红霉素是一种独特的大环内酯类抗生素，对化脓性链球菌、无乳链球菌、除耐甲氧西林金黄色葡萄球菌外的金黄色葡萄球菌、卡他莫拉菌（B群）和肺炎支原体保持强效活性。
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