Romero P, Cerottini J C, Waanders G A
Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, Lausanne, Switzerland.
Mol Med Today. 1998 Jul;4(7):305-12. doi: 10.1016/s1357-4310(98)01280-5.
Monitoring cytotoxic T lymphocyte (CTL) responses to tumor antigens that have been defined at the molecular level has become essential to assess novel approaches to the specific immunotherapy of cancer. Nevertheless, because of the low affinity of the interactions between T-cell receptors and their ligands, there are no straightforward, well-standardized methods to meet this need. In this review, we describe several novel methods to track antigen-specific CTL responses.
监测细胞毒性T淋巴细胞（CTL）对已在分子水平定义的肿瘤抗原的反应，对于评估癌症特异性免疫治疗的新方法至关重要。然而，由于T细胞受体与其配体之间相互作用的亲和力较低，目前尚无直接、标准化的方法来满足这一需求。在本综述中，我们描述了几种追踪抗原特异性CTL反应的新方法。
