Ilias I, Tselebis A, Boufas A, Panoutsopoulos G, Filippou N, Christakopoulou J
Department of Medicine, Sotiria Chest Diseases Hospital, Athens, Greece.
Int J Clin Pract. 1998 Jun;52(4):227-8.
Basal thyrotropin, total thyroxine, total tri-iodothyronine and free tri-iodothyronine were measured in 30 HIV-negative patients with focal pulmonary tuberculosis upon starting and after one and two weeks of isoniazid, rifampicin and pyrazinamide therapy. Rapid and statistically significant elevations in free tri-iodothyronine and total tri-iodothyronine were noted after the first and second week of treatment respectively. For most patients, however, hormone levels remained within normal limits throughout the study. Overall, the effects of pulmonary tuberculosis and of its therapy on the thyroid function parameters examined, in otherwise healthy individuals, appear to be minimal.
在30例局灶性肺结核的HIV阴性患者开始接受异烟肼、利福平及吡嗪酰胺治疗时，以及治疗1周和2周后，分别检测了基础促甲状腺激素、总甲状腺素、总三碘甲状腺原氨酸及游离三碘甲状腺原氨酸。在治疗第1周和第2周后，分别观察到游离三碘甲状腺原氨酸和总三碘甲状腺原氨酸迅速且有统计学意义的升高。然而，对于大多数患者而言，在整个研究过程中激素水平仍保持在正常范围内。总体而言，在其他方面健康的个体中，肺结核及其治疗对所检测的甲状腺功能参数的影响似乎很小。
