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健康习惯与老年认知障碍和痴呆风险:一项关于运动、吸烟和饮酒影响的前瞻性研究。

Health habits and risk of cognitive impairment and dementia in old age: a prospective study on the effects of exercise, smoking and alcohol consumption.

作者信息

Broe G A, Creasey H, Jorm A F, Bennett H P, Casey B, Waite L M, Grayson D A, Cullen J

机构信息

Centre for Education and Research on Ageing, University of Sydney, New South Wales.

出版信息

Aust N Z J Public Health. 1998 Aug;22(5):621-3. doi: 10.1111/j.1467-842x.1998.tb01449.x.

Abstract

Previous research has yielded inconsistent results on the effects of exercise, smoking and alcohol use on cognitive impairment and dementia in old age. We analysed data from the Sydney Older Persons Study to see if these health habits were associated with cognitive functioning, dementia or Alzheimer's disease. Health habits were assessed in Wave 1 of the study, when the subjects were aged 75 years or over. Three years later, the subjects were tested for cognitive functioning and clinically examined for dementia and Alzheimer's disease. The analysis was restricted to the 327 subjects examined in Wave 2 who were non-demented in Wave 1. There were few significant associations between health habits and cognitive performance and these were not found consistently across cognitive measures. No associations were found with dementia or Alzheimer's disease. While these health habits do not affect risk for dementia and cognitive impairment in the very elderly, who are at highest risk for these disorders, we cannot discount a role at younger ages.

摘要

先前的研究在运动、吸烟和饮酒对老年人认知障碍及痴呆症的影响方面得出了不一致的结果。我们分析了悉尼老年人研究的数据,以探究这些健康习惯是否与认知功能、痴呆症或阿尔茨海默病有关。在该研究的第1阶段评估健康习惯,当时受试者年龄在75岁及以上。三年后,对受试者进行认知功能测试,并对痴呆症和阿尔茨海默病进行临床检查。分析仅限于在第2阶段接受检查且在第1阶段未患痴呆症的327名受试者。健康习惯与认知表现之间几乎没有显著关联,而且在各项认知测量中也未一致发现这些关联。未发现与痴呆症或阿尔茨海默病有关联。虽然这些健康习惯对患痴呆症和认知障碍风险最高的高龄老年人并无影响,但我们不能排除其在较年轻时所起的作用。

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