Garrigue S, Barold S S, Cazeau S, Gencel L, Jaïs P, Haissaguerre M, Clémenty J
Hôpital Cardiologique du Haut-Lévêque, University of Bordeaux, Pessac, France.
Pacing Clin Electrophysiol. 1998 Sep;21(9):1751-9. doi: 10.1111/j.1540-8159.1998.tb00275.x.
We evaluated the effect of atrial overdrive on the incidence of atrial arrhythmias (AA) in 22 patients (67 +/- 9 years, 7 women, 15 men) with Chorus 6234 DDD pacemakers. Atrial overdrive was defined as a programmed paced rate 10 ppm faster than the mean ventricular rate stored for the last 24-hour period in the pacemaker memory. The protocol consisted of three phases of 1 month each. Phase I: observation after discontinuation of antiarrhythmic therapy. Phase II: arrhythmia analysis using the pacemaker memory after programming the lower rate to 55 ppm. The fallback function and histogram data were used to document the number and maximal duration of AA episodes as well as the total AA time in a month. Phase III: atrial overdrive. The mean ventricular heart rate was 65 +/- 4 beats/min before atrial overdrive versus 75 +/- 5 with atrial overdrive (P = 0.02). At the end of phase II, all patients presented with AA episodes (mean number per patient: 42 +/- 78 in one month). In phase III (with atrial overdrive), 14 (64.6%) patients had no recorded AA (group A). In the other eight patients with persistent AA episodes in phase III (group B), there was a significant reduction in the number of AA episodes (90 +/- 106 in phase II vs 38 +/- 87 in phase III; P = 0.01), their total duration (166 +/- 115 in phase II vs 92 +/- 134 hours in phase III; P = 0.03) and their maximal duration (121 +/- 103 in phase II vs 85 +/- 89 min; P = 0.04). Our short-term data suggest that atrial overdrive prevents or reduces AA episodes and demonstrate the feasibility and need of long-term studies to determine whether this benefit is sustained.
