Hatalski C G, Guirguis C, Baram T Z
Department of Anatomy, University of California, Irvine, USA.
J Neuroendocrinol. 1998 Sep;10(9):663-9. doi: 10.1046/j.1365-2826.1998.00246.x.
Age-appropriate acute stress, such as cold exposure, provokes the secretion of corticotropin releasing factor (CRF) from the hypothalamus, leading to a robust increase of plasma corticosterone in the immature rat. This activation of the hypothalamic-pituitary-adrenal system is accompanied by a stress-induced increase of steady-state CRF-mRNA expression in the hypothalamic paraventricular nucleus (PVN). In the current study, we analysed changes in CRF-mRNA expression in the PVN and the central nucleus of the amygdala (ACe) in the immature rat in response to a single episode of cold stress and three repeated exposures to this same stressor. CRF-mRNA expression in the PVN increased after a single, but not repeated exposures to cold stress, while repeated acute stress increased the content of the CRF peptide in the anterior hypothalamus. In the ACe, repeated episodes of cold stress resulted in increased expression of CRF-mRNA. These findings indicate a differential regulation of CRF gene expression in the PVN and ACe of the immature rat by single and repeated acute stress.
与年龄相符的急性应激，如寒冷暴露，会促使下丘脑分泌促肾上腺皮质激素释放因子（CRF），导致未成熟大鼠血浆皮质酮显著增加。下丘脑-垂体-肾上腺系统的这种激活伴随着应激诱导的下丘脑室旁核（PVN）中CRF mRNA稳态表达的增加。在本研究中，我们分析了未成熟大鼠在单次冷应激和三次重复暴露于相同应激源后，PVN和杏仁核中央核（ACe）中CRF mRNA表达的变化。单次而非重复暴露于冷应激后，PVN中的CRF mRNA表达增加，而重复急性应激则增加了下丘脑前部CRF肽的含量。在ACe中，重复的冷应激发作导致CRF mRNA表达增加。这些发现表明，单次和重复急性应激对未成熟大鼠PVN和ACe中CRF基因表达的调节存在差异。
