有证据表明，一种HLA - DQA1 - DQB1单倍型会影响男孩患儿童常见急性淋巴细胞白血病的易感性，这为感染相关病因提供了进一步的支持。
Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
作者信息
Taylor G M, Dearden S, Payne N, Ayres M, Gokhale D A, Birch J M, Blair V, Stevens R F, Will A M, Eden O B
机构信息
Immunogenetics Laboratory, St Mary's Hospital, Manchester, UK.
出版信息
Br J Cancer. 1998 Sep;78(5):561-5. doi: 10.1038/bjc.1998.540.
Abstract
Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/0104 and DQB10501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.
摘要
对60例儿童普通急性淋巴细胞白血病（c-ALL）患者和78例新生儿对照受试者的DQA1和DQB1等位基因进行比较，结果显示男性而非女性患者的DQA1*0101/0104和DQB10501频率高于相应的对照受试者。结果提示c-ALL存在与男性相关的易感单倍型，并支持感染性病因。
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