Nishikawa J, Kawai H, Takahashi A, Seki T, Yoshikawa N, Akita Y, Mitamura K
Second Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Gastrointest Endosc. 1998 Sep;48(3):237-43. doi: 10.1016/s0016-5107(98)70184-1.
The seroprevalence of immunoglobulin G antibodies against Helicobacter pylori in endoscopy personnel was determined to investigate whether gastrointestinal endoscopists and endoscopy nurses in Japan are at an increased risk for H. pylori infection and to clarify risk factors for H. pylori infection during endoscopy.
One hundred twenty-one gastrointestinal endoscopists and endoscopy nurses provided personal information, including their observance of infection-control measures, by means of self-administered questionnaire. One hundred one age-matched healthy individuals undergoing routine physical examinations served as controls. Serum samples from each subject were examined with enzyme-linked immunosorbent assay for the presence of IgG antibodies against H. pylori.
Among younger subjects (< 40 years old), endoscopists and endoscopy nurses had higher seropositive rates than did control subjects (p < 0.05). Among older subjects (> or = 40 years old), the seropositive rate did not differ between endoscopy personnel and control subjects (p = 0.2174). However, among older seropositive subjects, endoscopy personnel had significantly higher antibody titers than did control subjects (p < 0.01). Older seropositive endoscopists performed significantly more examinations per month than did their seronegative colleagues (p < 0.05). Furthermore, younger seropositive endoscopy nurses performed significantly more examinations per month than did seronegative nurses (p < 0.05).
Gastrointestinal endoscopists and endoscopy nurses in Japan are at high risk for H. pylori infection. The risk of H. pylori infection is correlated with the frequency of endoscopic examinations, especially in older gastrointestinal endoscopists and younger endoscopy nurses.
测定内镜检查人员中抗幽门螺杆菌免疫球蛋白G抗体的血清阳性率，以调查日本的胃肠内镜医师和内镜护士感染幽门螺杆菌的风险是否增加，并明确内镜检查期间幽门螺杆菌感染的危险因素。
121名胃肠内镜医师和内镜护士通过自行填写问卷提供个人信息，包括他们对感染控制措施的遵守情况。101名年龄匹配的接受常规体检的健康个体作为对照。用酶联免疫吸附测定法检测每个受试者血清样本中抗幽门螺杆菌IgG抗体的存在情况。
在较年轻的受试者（<40岁）中，内镜医师和内镜护士的血清阳性率高于对照受试者（p<0.05）。在较年长的受试者（≥40岁）中，内镜检查人员和对照受试者的血清阳性率没有差异（p = 0.2174）。然而，在年长的血清阳性受试者中，内镜检查人员的抗体滴度显著高于对照受试者（p<0.01）。年长的血清阳性内镜医师每月进行的检查显著多于血清阴性的同事（p<0.05）。此外，较年轻的血清阳性内镜护士每月进行的检查显著多于血清阴性的护士（p<0.05）。
日本的胃肠内镜医师和内镜护士感染幽门螺杆菌的风险很高。幽门螺杆菌感染风险与内镜检查频率相关，尤其是在年长的胃肠内镜医师和较年轻的内镜护士中。
