Lin S K, Lambert J R, Schembri M A, Nicholson L, Korman M G
Gastrointestinal Science Group, Monash Medical Centre, Melbourne, Victoria, Australia.
J Gastroenterol Hepatol. 1994 Jul-Aug;9(4):319-24. doi: 10.1111/j.1440-1746.1994.tb01249.x.
The epidemiology and mode of transmission of Helicobacter pylori is currently unclear; it is postulated that the human stomach is the natural reservoir and that spread occurs by faecal-oral or oral-oral transmission. The aim of this study was to assess the prevalence of H. pylori in gastroenterologists and gastroenterology nurses compared with internists, general nurses and the normal population. An enzyme-linked immunosorbent assay technique (sensitivity 96%, specificity 88%) was used to detect circulating H. pylori immunoglobulin G antibodies in 39 gastroenterologists, 107 gastroenterology nurses, 25 internists and 42 general nurses. These subjects were compared to an age- and sex-matched Caucasian population obtained by random sampling of an urban population area. The overall prevalence of H. pylori in gastroenterologists was 69% compared to 40% of internists (P < 0.01), 17% of gastroenterology nurses (P < 0.001), 19% of general nurses (P < 0.01) and 32% of controls (P < 0.01). There was no significant difference in H. pylori prevalence between the gastroenterology nurses and controls, general nurses and controls. The prevalence in gastroenterologists increased with years of practice to levels greater than age-matched controls. The prevalence in gastroenterology nurses increased with age and years of working and was similar to age-matched control subjects. These findings of an increased prevalence of H. pylori infection in gastroenterologists performing endoscopy support human-to-human transmission possibly from patients to medical staff.
幽门螺杆菌的流行病学及传播模式目前尚不清楚；据推测，人类胃部是其自然宿主，传播途径为粪口传播或口口传播。本研究旨在评估胃肠病学家和胃肠病学护士中幽门螺杆菌的感染率，并与内科医生、普通护士及正常人群进行比较。采用酶联免疫吸附测定技术（灵敏度96%，特异性88%）检测39名胃肠病学家、107名胃肠病学护士、25名内科医生和42名普通护士体内循环的幽门螺杆菌免疫球蛋白G抗体。将这些受试者与通过对城市人口区域随机抽样获得的年龄和性别匹配的白种人群进行比较。胃肠病学家中幽门螺杆菌的总体感染率为69%，而内科医生为40%（P<0.01），胃肠病学护士为17%（P<0.001），普通护士为19%（P<0.01），对照组为32%（P<0.01）。胃肠病学护士与对照组、普通护士与对照组之间幽门螺杆菌感染率无显著差异。胃肠病学家的感染率随从业年限增加，高于年龄匹配的对照组。胃肠病学护士的感染率随年龄和工作年限增加，与年龄匹配的对照受试者相似。这些在内镜检查的胃肠病学家中幽门螺杆菌感染率增加的发现支持了可能从患者到医护人员的人际传播。
