Neuberger J
Queen Elizabeth Hospital, Birmingham, UK.
Eur J Gastroenterol Hepatol. 1998 Aug;10(8):631-3.
Halothane, an effective and usually safe anaesthetic agent, is rarely associated with the development of fulminant hepatic failure. Guidelines have been developed to reduce the probability of a patient developing halothane hepatitis. However, cases continue to occur and, in some cases, the guidelines have been ignored. Stricter adherence to the guidelines will reduce, but not totally prevent, further cases from occurring. Once halothane hepatitis has developed, there are no specific treatments and liver replacement may be required. Halothane hepatitis is a paradigm for immune mediated adverse drug reactions. The mechanism appears to be related to development of sensitization to both autoantigens (including CYP2D6) and halothane-altered liver cell determinants.
氟烷是一种有效且通常安全的麻醉剂，很少与暴发性肝衰竭的发生相关。已制定指南以降低患者发生氟烷性肝炎的可能性。然而，病例仍在继续出现，并且在某些情况下，这些指南被忽视了。更严格地遵守这些指南将减少但不能完全防止进一步的病例发生。一旦发生氟烷性肝炎，没有特效治疗方法，可能需要进行肝脏置换。氟烷性肝炎是免疫介导的药物不良反应的一个范例。其机制似乎与自身抗原（包括细胞色素P450 2D6）和氟烷改变的肝细胞决定簇的致敏作用有关。
