Hasan F
Department of Medicine, Kuwait University, Safat, Kuwait.
Hepatogastroenterology. 1998 Mar-Apr;45(20):518-22.
Halogenated volatile anesthetics have been associated with liver injury. Most reported cases have been linked to halothane and enflurane. Cross-sensitization between the latter agents has also been documented. Isoflurane hepatitis is extremely rare, and only a few convincing cases have been published. Moreover, clinical cases of cross-sensitization of isoflurance with other haloalkanes have not been reported. We describe a case of hepatic dysfunction 2 weeks after isoflurance anesthesia in a 35-year-old obese woman with a previous history of halothane hepatitis. The diagnosis was made on the basis of exposure to isoflurance, the delay between the time of exposure and the onset of jaundice, and the exclusion of other causes of liver dysfunction. This case reiterates the recommendation that patients who sustain liver injury from one haloalkane should not be exposed to another.
卤代挥发性麻醉剂与肝损伤有关。大多数报告的病例与氟烷和恩氟烷有关。后者之间的交叉致敏也有文献记载。异氟烷肝炎极为罕见，仅有少数令人信服的病例发表。此外，尚未有关于异氟烷与其他卤代烷交叉致敏的临床病例报道。我们描述了一例35岁肥胖女性，有氟烷肝炎病史，在接受异氟烷麻醉2周后出现肝功能障碍的病例。诊断基于接触异氟烷、接触时间与黄疸发作之间的延迟以及排除其他肝功能障碍原因。该病例再次强调了一项建议，即因一种卤代烷导致肝损伤的患者不应接触另一种卤代烷。
