Mjahed K, Sadraoui A, Salmi S, Laraki M, Benaguida M
Département d'anesthésie-réanimation, CHU Ibn Rochd Casablanca, Maroc.
Ann Fr Anesth Reanim. 1997;16(5):531-3. doi: 10.1016/s0750-7658(97)83348-5.
A 3-year-old boy, who underwent multiple anaesthetics including halothane in a short period of time, developed 3 days after the last operation abdominal pain, jaundice and fever. Laboratory tests showed hepatic failure, with cytolysis, cholestasis and eosinophilia. Tests for hepatitis A, B, C, CMV and EBV were negative. No other causes of postoperative jaundice were identified. Despite symptomatic treatment, the child died 5 days after the last anaesthetic. Post mortem liver biopsy showed massive hepatic necrosis. The authors discuss factors increasing the risk for halothane-hepatitis, especially multiple exposures.
一名3岁男孩在短时间内接受了包括氟烷在内的多次麻醉，在最后一次手术后3天出现腹痛、黄疸和发热。实验室检查显示肝功能衰竭，伴有细胞溶解、胆汁淤积和嗜酸性粒细胞增多。甲型、乙型、丙型肝炎病毒、巨细胞病毒和EB病毒检测均为阴性。未发现术后黄疸的其他原因。尽管进行了对症治疗，患儿在最后一次麻醉后5天死亡。尸检肝脏活检显示大量肝坏死。作者讨论了增加氟烷性肝炎风险的因素，尤其是多次接触。
