Yamamoto T, Tsuchihashi T, Hayashi J, Kashiwagi S
Department of General Medicine Kyushu University Hospital, Fukuoka.
Fukuoka Igaku Zasshi. 1998 Jul;89(7):207-15.
We investigated the hypothesis that interferon-induced hyperadrenergic state causes cardiovascular events. Thirteen patients with chronic hepatitis C who were scheduled to undergo interferon therapy were randomly selected for this study. Heart rate was monitored and urinary levels of catecholamines were measured before, on the 1st day, and after 1 week and 4 weeks of treatment. On the 1st day, 24-hr average heart rate and hourly average heart rate were significantly higher than those before treatment, although they returned to baseline levels after 1 week and 4 weeks. However, urinary levels of cathecholamines did not change significantly on the 1st day of interferon therapy. Although the direct evidence that interferon stimulates sympathetic nervous system could not be obtained, interferon elicited tachycardic response and may have increased the risk of arrhythmias of the 1st day of the treatment.
我们研究了干扰素诱导的高肾上腺素能状态导致心血管事件这一假说。本研究随机选取了13例计划接受干扰素治疗的慢性丙型肝炎患者。在治疗前、治疗第1天、治疗1周和4周后监测心率并测量尿儿茶酚胺水平。治疗第1天，24小时平均心率和每小时平均心率显著高于治疗前，尽管在1周和4周后恢复到基线水平。然而，干扰素治疗第1天尿儿茶酚胺水平无显著变化。虽然未能获得干扰素刺激交感神经系统的直接证据，但干扰素引起了心动过速反应，可能增加了治疗第1天心律失常的风险。
