Toccaceli F, Rosati S, Scuderi M, Iacomi F, Picconi R, Laghi V
Department of Infectious and Tropical Diseases, La Sapienza University, Policlinico Umberto I, Rome, Italy.
Hepatogastroenterology. 1998 Sep-Oct;45(23):1748-52.
BACKGROUND/AIMS: The hematologic toxicity (leukothrombocytopenia) of interferon therapy is well known and frequently observed; it may vary, however, according to the type of interferon administered.
We retrospectively assessed 158 patients with chronic viral hepatitis treated for 6-12 months with alpha (recombinant, lymphoblastoid or leukocyte) or beta interferon to monitor leukothrombocytopenia.
During treatment, a significant decrease in leukocyte and platelet counts was detected in 48% and 43% of patients, respectively. The maximum decrease (31% and 26% of pre-treatment values; p<0.01) occurred after 4.9 and 4.2 months of treatment. No patient showed clinical symptoms of leukopenia or thrombocytopenia. Beta-interferon yielded the smallest decreases in leukocyte and platelet counts (-21% and -16% of pre-treatment values, respectively). Among alpha interferons, the lymphoblastoid (9 MU/week) produced the largest decrease both in leukocyte (38%; p<0.05 vs any other type) and in platelet (32%) number. The same dose of leukocyte interferon had the smallest effect (leukocytes: -27%; platelets: -2%), while recombinant interferon showed intermediate toxicity (-32% and -26% respectively).
From this retrospective study, the hematologic toxicity of alpha and alpha interferons usually emerges as mild. However, leukopenia and thrombocytopenia may be induced more frequently by some of these interferon types.
背景/目的：干扰素治疗的血液学毒性（白细胞血小板减少症）众所周知且经常可见；然而，其可能因所使用的干扰素类型而异。
我们回顾性评估了158例接受α（重组、淋巴母细胞样或白细胞）或β干扰素治疗6至12个月的慢性病毒性肝炎患者，以监测白细胞血小板减少症。
治疗期间，分别有48%和43%的患者白细胞和血小板计数显著下降。最大降幅（降至治疗前值的31%和26%；p<0.01）出现在治疗4.9个月和4.2个月后。没有患者出现白细胞减少或血小板减少的临床症状。β干扰素导致的白细胞和血小板计数降幅最小（分别降至治疗前值的-21%和-16%）。在α干扰素中，淋巴母细胞样干扰素（9 MU/周）导致的白细胞（38%；与其他任何类型相比，p<0.05）和血小板数量降幅最大（32%）。相同剂量的白细胞干扰素效果最小（白细胞：-27%；血小板：-2%），而重组干扰素显示出中等毒性（分别为-32%和-26%）。
从这项回顾性研究来看，α和β干扰素的血液学毒性通常表现为轻度。然而，其中某些类型的干扰素可能更频繁地诱发白细胞减少和血小板减少。
