Inoue S, Ohfu M, Morooka T, Tsuru N, Mitsudome A, Narita M
Department of Pediatrics, Chikushi Hospital, Fukuoka University.
Kansenshogaku Zasshi. 1998 Jul;72(7):771-5. doi: 10.11150/kansenshogakuzasshi1970.72.771.
A 9-year-old female was admitted to our hospital due to a generalized seizure and consciousness disturbance. The patient had a fever and rash four days before admission, but she had no respiratory symptoms. The seizure and consciousness disturbance was prolonged and intractable. We diagnosed the patient as having encephalitis because of the increase in the cell count in the cerebrospinal fluid (CSF) and a diffuse slow EEG wave. The computed tomography of the head was normal. The causative agent was identified as Mycoplasma pneumoniae because of the increase of antibodies, and the detection of a specific DNA with a polymerase chain reaction. The interleukin (IL)-6 level of CSF was high (384 pg/ml). In spite of intensive treatment she had severe neurological sequelae. The invasion of Mycoplasma pneumoniae to the central nervous system appeared to have a role in the development of encephalitis in the patient. We speculated that there is a possible relationship between the IL-6 levels of CSF and clinical severity of encephalitis.
一名9岁女性因全身性癫痫发作和意识障碍入院。患者入院前四天出现发热和皮疹，但无呼吸道症状。癫痫发作和意识障碍持续时间长且难以控制。由于脑脊液（CSF）细胞计数增加和脑电图弥漫性慢波，我们诊断该患者患有脑炎。头部计算机断层扫描正常。由于抗体增加以及通过聚合酶链反应检测到特定DNA，病原体被鉴定为肺炎支原体。脑脊液白细胞介素（IL）-6水平较高（384 pg/ml）。尽管进行了强化治疗，她仍有严重的神经后遗症。肺炎支原体侵入中枢神经系统似乎在该患者脑炎的发生中起作用。我们推测脑脊液IL-6水平与脑炎临床严重程度之间可能存在关联。
