Suzuki S, Sato K, Taniguchi M, Miyagawa K, Kojima M, Dohi Y, Ueda R
Division of Cardiology, Nagoya City Johoku Hospital, Japan.
Nihon Ronen Igakkai Zasshi. 1998 Jun;35(6):444-50. doi: 10.3143/geriatrics.35.444.
Calcified aortic value disease is increasing with explosively in the elderly. Elevated serum lipoprotein(a) (Lp(a) plays an important role in the pathogenesis of atherosclerosis. Thus, we investigated the relationship between aortic valve sclerosis and serum Lp(a) levels in elderly patients.
Echocardiography was performed in 97 subjects (77 +/- 7 years, 48 males and 49 females), Lp(a), fasting plasma glucose, and blood pressure were measured at the time of the study. Aortic valve sclerosis was assessed using echocardiography.
Aortic valve sclerosis was observed in 63 patients (sclerosis group; 24 males and 39 females) and not in 34 subjects (non-sclerosis group; 24 males and 10 females). Univariable analysis revealed that age, Lp(a) level, and the number of females were higher in the sclerosis group than in the non-sclerosis group (age; 78 +/- 7 vs 74 +/- 7 years, p = 0.0090, Lp(a); cholesterol, triglyceride, and fasting blood glucose did not seem to affect aortic valve sclerosis. In all of 9 patients with serum Lp(a) greater than 60mg/dl aortic valve sclerosis was present. In discriminative analysis, gender (female) (lambda = 0.9038, p = 0.0020) and Lp(a) (lambda = 0.8316, p = 0.0053) were related to aortic valve sclerosis.
Elevated serum Lp(a) was observed in elderly patients with aortic valve sclerosis.
钙化性主动脉瓣疾病在老年人中呈爆发式增长。血清脂蛋白(a)[Lp(a)]升高在动脉粥样硬化发病机制中起重要作用。因此，我们研究了老年患者主动脉瓣硬化与血清Lp(a)水平之间的关系。
对97名受试者（年龄77±7岁，男性48名，女性49名）进行了超声心动图检查，在研究时测量了Lp(a)、空腹血糖和血压。使用超声心动图评估主动脉瓣硬化情况。
63例患者观察到主动脉瓣硬化（硬化组；男性24名，女性39名），34名受试者未观察到（非硬化组；男性24名，女性10名）。单变量分析显示，硬化组的年龄、Lp(a)水平和女性人数高于非硬化组（年龄：78±7岁对74±7岁，p=0.0090；Lp(a)……胆固醇、甘油三酯和空腹血糖似乎不影响主动脉瓣硬化。在所有9例血清Lp(a)大于60mg/dl的患者中均存在主动脉瓣硬化。在判别分析中，性别（女性）（λ=0.9038，p=0.0020）和Lp(a)（λ=0.8316，p=0.0053）与主动脉瓣硬化有关。
在患有主动脉瓣硬化的老年患者中观察到血清Lp(a)升高。
