Saxena P R, De Vries P, Villalón C M
Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasums University, Rotterdam, The Netherlands.
Trends Pharmacol Sci. 1998 Aug;19(8):311-6. doi: 10.1016/s0165-6147(98)01228-0.
It is exactly half a century ago that 5-hydroxytryptamine was discovered and over four decades ago two types of 5-HT receptors were described. In this article, Pramod Saxena, Peter De Vries and Carlos Villalón trace the development of the modern classification and nomenclature of 5-HT receptors, which now include more than a dozen subtypes. In doing so, they advocate that the so-called '5-HT1-like' receptors, having been shown to be a heterogeneous population of 5-HT1B, 5-HT1D and 5-HT7 receptors, are now redundant.
5-羟色胺是在整整半个世纪前被发现的，而两种类型的5-羟色胺（5-HT）受体则是在四十多年前被描述的。在本文中，普拉莫德·萨克森纳、彼得·德弗里斯和卡洛斯·比利亚隆追溯了5-HT受体现代分类和命名法的发展历程，目前该分类包括十几种亚型。在此过程中，他们主张所谓的“5-HT1样”受体，现已被证明是由5-HT1B、5-HT1D和5-HT7受体组成的异质群体，如今已不再适用。
