混合嵌合体诱导免疫耐受：在临床复合组织移植中的潜在应用。 - Suppr | 超能文献

Mixed chimerism for the induction of tolerance: potential applicability in clinical composite tissue grafting.

作者信息

Wekerle T, Sachs D H, Sykes M

机构信息

Bone Marrow Transplantation Section, Massachusetts General Hospital, Boston 02129, USA.

出版信息

Transplant Proc. 1998 Sep;30(6):2708-10. doi: 10.1016/s0041-1345(98)00793-3.

DOI:10.1016/s0041-1345(98)00793-3

Abstract

摘要

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Mixed chimerism for the induction of tolerance: potential applicability in clinical composite tissue grafting.混合嵌合体诱导免疫耐受：在临床复合组织移植中的潜在应用。

Transplant Proc. 1998 Sep;30(6):2708-10. doi: 10.1016/s0041-1345(98)00793-3.

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Hematopoietic chimerism, tolerance induction and graft-versus-host disease: considerations for composite tissue transfer.

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Deletion of donor-reactive cells followed by stem cell transplantation in recipients treated with total lymphoid-irradiation as a means for induction of transplantation tolerance to organ allografts and xenografts.在接受全身淋巴照射的受体中，先清除供体反应性细胞，然后进行干细胞移植，以此作为诱导对器官同种异体移植和异种移植产生移植耐受的一种手段。

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4

Additional monoclonal antibody (mAB) injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation.额外的单克隆抗体（mAB）注射可以替代胸腺照射，从而在经抗T细胞mAB和3戈瑞全身照射预处理后接受骨髓移植的小鼠中诱导混合嵌合体形成和耐受。

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Mesenchymal stem cells enhance the induction of mixed chimerism and tolerance to rat hind-limb allografts after bone marrow transplantation.间充质干细胞增强骨髓移植后大鼠后肢同种异体移植物混合嵌合体的诱导和耐受。

J Surg Res. 2010 May 15;160(2):315-24. doi: 10.1016/j.jss.2008.09.027. Epub 2008 Nov 4.

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Basic science foundation for clinical composite tissue transplantation.临床复合组织移植的基础科学依据

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Short-term immunosuppression facilitates induction of mixed chimerism and tolerance after bone marrow transplantation without cytoreductive conditioning.短期免疫抑制有助于在无细胞减灭预处理的情况下诱导骨髓移植后的混合嵌合体形成和免疫耐受。

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Update and outline of the experimental problems facing clinical composite tissue transplantation.临床复合组织移植面临的实验问题更新与概述

Transplant Proc. 1998 Sep;30(6):2704-7. doi: 10.1016/s0041-1345(98)00792-1.

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The combined use of sublethal irradiation and costimulatory blockade to generate mixed bone marrow chimeras.亚致死剂量照射与共刺激阻断联合使用以产生混合骨髓嵌合体。

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Mixed chimerism and transplantation tolerance induced by a nonlethal preparative regimen in cynomolgus monkeys.

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