Lee W P, Rubin J P, Cober S, Ierino F, Randolph M A, Sachs D H
Plastic Surgery Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
Transplant Proc. 1998 Sep;30(6):2743-5. doi: 10.1016/s0041-1345(98)00801-x.
Permanent tolerance to vascularized skeletal tissue allografts can be induced in miniature swine with minor antigen differences using a 12-day course of CsA. Demonstration of skeletal tissue allograft survival in a large animal model without long-term immunosuppression represents an important step toward transplantation of skeletal tissue allografts in humans.
使用12天疗程的环孢素A（CsA），可在具有微小抗原差异的小型猪中诱导对血管化骨骼组织同种异体移植物的永久耐受性。在大型动物模型中证明骨骼组织同种异体移植物在无长期免疫抑制的情况下存活，是朝着在人类中移植骨骼组织同种异体移植物迈出的重要一步。
