Strong R
Department of Pharmacology, University of Texas Health Science Center at San Antonio, USA.
Geriatrics. 1998 Sep;53 Suppl 1:S9-12.
Neurotransmission is impaired in age-related disorders, such as Alzheimer's and Parkinson's diseases, which has prompted many investigations into the neurochemistry of the aging human brain. Of all the neurotransmitter systems studied, age-related changes in parameters of the serotonergic, cholinergic, and dopaminergic systems are the most reliably measured. The association of these neurotransmitters, respectively, with mood, memory, and motor function has fueled interest in how changes in neurochemistry may contribute to age-associated behavioral changes and possibly predispose older persons to diseases of late life. The evidence suggests that impaired neurotransmission may be responsible for at least some of the behavioral abnormalities associated with aging. Moreover, age-related neurodegenerative diseases may evolve from the interaction between defects in specific neurochemical mechanisms and as-yet undefined pathophysiologic processes.
神经传递在与年龄相关的疾病中受损，如阿尔茨海默病和帕金森病，这促使人们对衰老的人类大脑的神经化学进行了许多研究。在所有研究的神经递质系统中，血清素能、胆碱能和多巴胺能系统参数的年龄相关变化是最可靠测量的。这些神经递质分别与情绪、记忆和运动功能的关联，激发了人们对神经化学变化如何导致与年龄相关的行为变化以及可能使老年人易患晚年疾病的兴趣。证据表明，神经传递受损可能至少是与衰老相关的一些行为异常的原因。此外，与年龄相关的神经退行性疾病可能源于特定神经化学机制缺陷与尚未明确的病理生理过程之间的相互作用。
