Haddad F, Debs R, Tohme A, Helou J, Ghayad E
Service de Médecine Interne, Hôtel-Dieu de France, Liban.
Ann Dermatol Venereol. 1998 Jan;125(1):24-6.
Werner's syndrome associates early aging in young adults, small height, cataract, glucose intolerance, hypogonadism, skin ulcers, vascular calcifications and osteoporosis.
We report a new case of Werner's syndrome in a 34-year-old man with suggestive alterations of the skin and endocrine anomalies in addition to hypospadias, urethral stenosis, bilateral mega-ureter and chronic renal failure.
The diagnosis of Werner's syndrome in our patient was unquestionable because of the clinical presentation and the familial context. However, the urology anomalies have not been reported in this syndrome. A simple coincidence cannot be excluded.
沃纳综合征与青年早老、身材矮小、白内障、葡萄糖不耐受、性腺功能减退、皮肤溃疡、血管钙化和骨质疏松相关。
我们报告一例34岁男性的沃纳综合征新病例，该患者除尿道下裂、尿道狭窄、双侧巨输尿管和慢性肾衰竭外，还有皮肤改变及内分泌异常的提示性表现。
鉴于临床表现和家族背景，我们患者的沃纳综合征诊断明确。然而，该综合征中尚未有泌尿外科异常的报道。不能排除单纯巧合的可能性。
