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表现为化脓性血栓性静脉炎的肠炎沙门氏菌败血症

[Salmonella enteritidis septicemia manifesting as a suppurated thrombophlebitis].

作者信息

Leccia M T, Aubry-Artignan S, Brion J P, Voirin L, Beani J C, Amblard P

机构信息

Service de Dermatologie, CHU A. Michallon, Grenoble.

出版信息

Ann Dermatol Venereol. 1998 Feb;125(2):108-10.

PMID:9747225
Abstract

BACKGROUND

Non-typloid salmonella can cause septicemia and extradigestive disorders in immunodepressed adults. These frequent diseases can be life-threatening.

CASE REPORT

A 76-year-old woman was treated with corticosteroid therapy for 1 year for suppurated thrombophlebitis of the right greater saphenous vein. Weight loss, fever at 41 degrees C and Salmonella enterididis isolated from blood cultures and skin samples led to the diagnosis of septicemia with multiple septic foyers including the venous endothelium and surrounding soft tissue.

DISCUSSION

In Western countries, there has been an uprise in the frequency of low-grade salmonella infections by food poisoning usually causing acute diarrhea. S. enterididis can also cause severe infectious syndromes with multiple septic localizations, main in patients with a compromised immune reaction. In our cases, Salmonella enteritidis septecemia was revealed by an unusual situation. In the literature, inaugural signs usually involve the heart or arteries, but our patient had isolated foyers involving the superficial venous network. This is exceptional especially since there was no iatrogenic venous catheter insult. For our patient, favoring factors were the long-term corticosteroid therapy and altered venous network. The portal of entry could not be clearly identified but the discovery of a sigmoid diverticulosis would be an argument favoring a digestive origin. Medical and surgical management with resection of the necrosed tissues and two adapted antibiotics in a long-term regimen led to a successful outcome.

摘要

背景

非伤寒沙门氏菌可在免疫功能低下的成年人中引起败血症和消化系统外疾病。这些常见疾病可能危及生命。

病例报告

一名76岁女性因右大隐静脉化脓性血栓性静脉炎接受了1年的皮质类固醇治疗。体重减轻、41摄氏度发热以及从血培养和皮肤样本中分离出肠炎沙门氏菌,导致诊断为败血症,伴有包括静脉内皮和周围软组织在内的多个败血症病灶。

讨论

在西方国家,因食物中毒导致的轻度沙门氏菌感染频率有所上升,通常引起急性腹泻。肠炎沙门氏菌也可导致严重的感染综合征,伴有多个败血症定位,主要发生在免疫反应受损的患者中。在我们的病例中,肠炎沙门氏菌败血症是由一种不寻常的情况揭示的。在文献中,首发症状通常涉及心脏或动脉,但我们的患者有涉及浅静脉网络的孤立病灶。这很罕见,尤其是因为没有医源性静脉导管损伤。对我们的患者来说,促发因素是长期的皮质类固醇治疗和静脉网络改变。无法明确确定感染途径,但发现乙状结肠憩室病可能支持消化源性。通过切除坏死组织以及长期使用两种合适的抗生素进行内科和外科治疗,取得了成功的结果。

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