Wagnieres G, Hadjur C, Grosjean P, Braichotte D, Savary J F, Monnier P, van den Bergh H
Institute of Environmental Engineering, Swiss Federal Institute of Technology, Lausanne, Switzerland.
Photochem Photobiol. 1998 Sep;68(3):382-7.
The cutaneous phototoxic reaction induced by intravenous injection of 5,-10,-15,-20-tetra(m-hydroxyphenyl)chlorin (mTHPC) has been clinically evaluated in patients undergoing photodynamic therapy. These tests were performed on the backs of 23 patients with a solar simulator at various times after drug administration ranging from 5 h to 57 days. The mTHPC doses ranged from 0.1 to 0.3 mg/kg, and the illuminations lasted from 30 s up to 8 min. These tests have shown that the duration of the skin photosensitization induced after a typical therapeutic dose of mTHPC (0.15 mg/kg) is less important than with Photofrin (2 mg/kg). The level of mTHPC in the skin was also assessed in vivo and at times corresponding to the irradiations using an optical fiber-based spectrofluorometer. This study indicates that the light-induced fluorescence spectroscopy of mTHPC enables prediction of the degree of photosensitivity of the skin.
静脉注射5,-10,-15,-20-四（间羟基苯基）二氢卟吩（mTHPC）所引发的皮肤光毒性反应已在接受光动力治疗的患者中进行了临床评估。这些测试在23名患者的背部进行，使用太阳模拟器，在给药后5小时至57天的不同时间进行。mTHPC剂量范围为0.1至0.3mg/kg，光照持续时间从30秒至8分钟。这些测试表明，典型治疗剂量的mTHPC（0.15mg/kg）诱导的皮肤光敏化持续时间比血卟啉衍生物（2mg/kg）的情况要次要。还使用基于光纤的荧光分光光度计在体内以及与照射相对应的时间评估了皮肤中mTHPC的水平。这项研究表明，mTHPC的光致荧光光谱能够预测皮肤的光敏程度。
