Cechetto D F, Kline R L
Robarts Research Institute and Department of Anatomy and Cell Biology, University of Western Ontario, Canada.
J Hypertens Suppl. 1998 Aug;16(3):S13-7.
Previously, changes in position and slope of the pressure-natriuresis relationship have been used to characterize antihypertensive drugs in basic research. Rilmenidine may chronically reduce arterial pressure via central nervous system and renal imidazoline receptors. The present experiments were used to examine the shift in the pressure-natriuresis relationship during rilmenidine administration. We examined the effects of twice daily doses (1 and 3 mg/kg) for 6 days on the pressure-natriuresis relationship determined for control and treated spontaneously hypertensive rats (SHR) drinking tap water or 1% NaCl. The pressure-natriuresis relationship was shifted to the left for the 3 mg/kg dose and the slope was no different from the control. These experiments also indicated that rilmenidine might have an effect on sodium preference which was confirmed in a third series of experiments by permitting control and treated (3 mg/kg) SHR access to both tap water and 1% NaCl. This lack of change in slope indicates that, during rilmenidine treatment, the arterial pressure is relatively insensitive to sodium intake. The shift to the left indicates a restoration of the pressure-natriuresis relationship after chronic treatment with rilmenidine and a resetting of the long-term blood pressure control. Rilmenidine also reduces salt appetite in the SHR.
此前，压力-利钠关系的位置和斜率变化已被用于基础研究中对抗高血压药物的特性描述。利美尼定可能通过中枢神经系统和肾脏咪唑啉受体长期降低动脉血压。本实验旨在研究利美尼定给药期间压力-利钠关系的变化。我们检测了连续6天每日两次给予（1和3mg/kg）剂量对饮用自来水或1%氯化钠的对照和治疗自发性高血压大鼠（SHR）的压力-利钠关系的影响。对于3mg/kg剂量，压力-利钠关系向左移动，斜率与对照无差异。这些实验还表明，利美尼定可能对钠偏好有影响，这在第三组实验中通过允许对照和治疗（3mg/kg）的SHR获取自来水和1%氯化钠得到了证实。斜率缺乏变化表明，在利美尼定治疗期间，动脉血压对钠摄入相对不敏感。向左移动表明利美尼定长期治疗后压力-利钠关系得以恢复，长期血压控制得以重置。利美尼定还降低了SHR的盐食欲。
