Okamoto H, Osawa H, Nakashima S, Takahashi S, Kasemura T, Nozawa Y
Faculty of Engineering, Department of Applies Chemistry, Gifu University, Japan.
J Biomater Sci Polym Ed. 1998;9(9):943-59. doi: 10.1163/156856298x00262.
Terpolymers composed of methyl methacrylate (MMA), polydimethylsiloxane methacrylate (PDMSMA), and methoxypolyethyleneglycol methacrylate (MPEGMA), having different compositions were synthesized. Platelets were not adsorbed onto terpolymer surfaces composed of 50 wt% MMA, 25 wt% PDMSMA and 25 wt% MPEGMA, while on terpolymers with the other compositions, platelet adsorption and fibrin clot were observed. It was shown that PDMS segment was predominant on these terpolymer surfaces via XPS. Receding contact angles of terpolymers, on which no platelet was observed, showed intermediate values between PDMS- and MPEG-rich surfaces. It was suggested that these terpolymers had blood compatibility.
合成了由甲基丙烯酸甲酯（MMA）、聚二甲基硅氧烷甲基丙烯酸酯（PDMSMA）和甲氧基聚乙二醇甲基丙烯酸酯（MPEGMA）组成的不同组成的三元共聚物。血小板不会吸附在由50 wt% MMA、25 wt% PDMSMA和25 wt% MPEGMA组成的三元共聚物表面，而在具有其他组成的三元共聚物表面，则观察到血小板吸附和纤维蛋白凝块。通过XPS表明，PDMS链段在这些三元共聚物表面占主导地位。未观察到血小板的三元共聚物的后退接触角显示出在富含PDMS和富含MPEG的表面之间的中间值。表明这些三元共聚物具有血液相容性。
