Onofrj M, Thomas A, Paci C, D'Andreamatteo G
Department of Oncology and Neuroscience, University G. D'Annunzio Chieti, Italy.
Neurology. 1998 Sep;51(3):880-2. doi: 10.1212/wnl.51.3.880.
We treated four patients affected by orthostatic tremor (OT) with gabapentin in increasing doses (300 to 2,400 mg/d). OT was evaluated with patients' self-monitoring scales, tremor rating scales, electromyography (EMG) showing the 14- to 18-Hz frequencies, and EMG frequency analysis. All patients had transitory responses to clonazepam. Gabapentin induced disappearance of OT in three patients and consistent reduction in one. Crossover to placebo induced reappearance of tremor.
我们使用加巴喷丁对4例患有直立性震颤（OT）的患者进行治疗，剂量逐渐增加（300至2400毫克/天）。通过患者自我监测量表、震颤评分量表、显示14至18赫兹频率的肌电图（EMG）以及EMG频率分析对OT进行评估。所有患者对氯硝西泮均有短暂反应。加巴喷丁使3例患者的OT消失，1例患者的OT持续减轻。换用安慰剂后震颤再次出现。
